新文章：槲皮素和癌症 - 过去 4 年的新研究 - 回顾了 5 篇论文
槲皮素是一种强效的黄酮类化合物，存在于多种植物、水果和蔬菜中。
它具有抗氧化、抗炎和抗癌作用。
大多数人服用槲皮素是为了治疗过敏和肥大细胞活化综合征，但其抗癌作用非常重要。
我回顾了过去五年有关槲皮素对癌症影响的文献。
槲皮素的主要抗癌作用包括：
- 调节 ROS（活性氧）
- 刺激癌细胞凋亡
- 刺激细胞周期停滞
- 刺激自噬
- 抑制肿瘤血管生成
- 抑制转移
- 槲皮素可以预防某些癌症的形成，主要是结直肠癌。
槲皮素的一些独特抗癌作用与那些接种辉瑞或 Moderna COVID-19 mRNA 疫苗并患上涡轮癌（乳腺癌、结直肠癌、肺癌、胰腺癌等）的人有关
- 槲皮素可稳定 p53 并提高 p53 水平，从而通过细胞凋亡导致癌细胞死亡（p53 被 COVID-19 mRNA 疫苗刺突蛋白破坏）
- 槲皮素能够杀死癌症干细胞（导致恶性癌症、转移和癌症复发 - Turbo Cancer 患者的预后极差，因为标准化疗不会杀死他们的癌症干细胞）
- 槲皮素调节与多种癌症有关的微小RNA（miR）（mRNA诱导的涡轮癌理论之一是致癌miR的存在或上调）
- 槲皮素对多种癌症的研究最为深入，其中乳腺癌和结直肠癌就是其中之一。
- 槲皮素在小鼠体内的研究表明其对乳腺癌、结肠直肠癌、肝癌、前列腺癌、肺癌、胰腺癌、黑色素瘤、白血病、胃癌具有抗癌作用。
槲皮素与许多其他治疗方法具有协同作用：
- 槲皮素与化疗具有协同作用，可提高杀死癌细胞的功效
- 槲皮素与放射疗法具有协同作用
- 槲皮素可逆转化疗药物耐药性（对于对标准化疗产生耐药性的 Turbo Cancer 患者至关重要）
- 槲皮素与生物活性化合物（白藜芦醇、绿茶儿茶素 EGCG）具有协同作用
槲皮素存在于多种植物中，每 100 克植物中含量最高的是洋葱（45 毫克）、牛至（42 毫克）、荞麦（36 毫克）、菠菜（27 毫克）、蔓越莓（25 毫克）、羽衣甘蓝（23 毫克）、樱桃（17 毫克）、蓝莓（15 毫克）、芦笋（14 毫克）。
槲皮素是安全的，目前已有许多生物利用度更高的配方。
槲皮素应包含在大多数“替代癌症治疗”方案中。
其中一些研究的结论：
“槲皮素作为天然产物，是一种黄酮类化合物，合理剂量的槲皮素无毒无害，且对多种肿瘤形成方式有抑制作用。”
“大量的体内外实验表明，槲皮素具有很强的促细胞凋亡、抑制转移作用，以及调节细胞周期和肿瘤血管生成的能力。槲皮素可以通过调节表观遗传学来影响肿瘤的发展，可以直接调节miRNA的表达和DNA甲基化水平，发挥抗癌作用，增强肿瘤细胞对化疗的敏感性”
“槲皮素具有一些显著的抗癌活性。研究表明，槲皮素通过调节与细胞凋亡和自噬相关的不同失调信号通路，利用多种机制发挥其抗癌作用”
“迫切需要在该领域进行不同的体内研究，以分析槲皮素的治疗活性和安全性。”
“在天然植物提取物中，槲皮素表现出多种显著的生物抗肿瘤作用。ncRNA（非编码RNA，包括miRNA和lncRNA长链非编码RNA）在癌症发展中起着关键作用。槲皮素调节ncRNA的表达，进而影响相关信号通路基因/蛋白质的表达，抑制癌细胞生长，促进细胞凋亡，增强对化疗药物的敏感性。总之，槲皮素是一种天然化合物，在癌症的辅助治疗中具有潜在的抗癌作用。”
NEW ARTICLE: QUERCETIN and CANCER - New research of the past 4 years - 5 papers reviewed
Quercetin is a powerful flavonoid found in a variety of plants, fruits and vegetables.
It has anti-oxidant, anti-inflammatory and anti-cancer effects.
Most people take Quercetin for allergies and Mast Cell Activation Syndrome, but the anti-cancer effects are very important.
I review the past 5 years worth of literature on the effects of Quercetin on CANCER.
Quercetin's main anti-cancer effects include:
- regulates ROS (reactive oxygen species)
- stimulates apoptosis of cancer cells
- stimulates cell cycle arrest
- stimulates autophagy
- inhibits angiogenesis in tumors
- inhibits metastases
- Quercetin can PREVENT certain cancers from forming, mainly Colorectal cancer.
Some of Quercetin's UNIQUE anti-cancer effects are relevant to those who took Pfizer or Moderna COVID-19 mRNA Vaccines and developed Turbo Cancer (breast cancer, colorectal cancer, lung cancer, pancreatic cancer, etc)
- Quercetin stabilizes p53 and increases p53 levels which leads to cancer cell death via apoptosis (p53 is damaged by COVID-19 mRNA Vaccine spike protein)
- Quercetin is able to kill CANCER STEM CELLS (responsible for aggressive cancers, metastases and cancer recurrence - Turbo Cancer patients have extremely poor prognosis because standard chemo doesn't kill their Cancer Stem Cells)
- Quercetin regulates microRNAs (miRs) which are implicated in many cancers (one of the theories on mRNA Induced Turbo Cancer is the presence or upregulation of oncogenic miRs)
- Best studied cancers with Quercetin are breast cancer and colorectal cancer.
- Quercetin in vivo mouse studies show anti-cancer effects in: breast, colorectal, liver, prostate, lung, pancreatic, melanoma, leukemia, gastric
Quercetin is synergistic with many other treatments:
- Quercetin is synergistic with chemo and increases efficacy of cancer cell killing
- Quercetin is synergistic with radiation therapy
- Quercetin reverses chemo drug resistance (crucial for Turbo Cancer patients who have resistance to standard chemotherapy treatments)
- Quercetin is synergistic with bioactive compounds (resveratrol, green tea catechins EGCG)
Quercetin is found in a variety of plants, highest concentrations in onions (45mg), oregano (42mg), buckwheat (36mg), spinach (27mg), cranberry (25mg), kale (23mg), cherries (17mg), blueberries (15mg), asparagus (14mg) per 100 grams.
Quercetin is safe and is now available in many formulations that are more bioavailable.
Quercetin should be in most "Alternative Cancer Treatment" regimens.
Conclusions of some of these studies:
“As a natural product, quercetin is a flavonoid compound, and treated with a reasonable dose of quercetin is non-toxic and has various inhibitory effects on various ways of tumor formation.”
“A large number of in vivo and in vitro experiments have shown that quercetin has a strong role in promoting apoptosis, inhibiting metastasis, and its ability to regulate cell cycle and tumor angiogenesis. Quercetin can influence the development of tumor by regulating epigenetics, which can directly regulate the expression of miRNA and the level of DNA methylation to exert anti-cancer effect and enhance the sensitivity of tumor cells to chemotherapy”
“Quercetin possesses some significant anticancer activities. It has been shown that quercetin uses multiple mechanisms to exert its anticancer effects by modulating different dysregulated signalling pathways which implicated apoptosis and autophagy”
“there is an urgent need for different in vivo studies in this field to analyze the therapeutic activities and safety of quercetins.”
“Among natural plant extracts, quercetin shows several significant biological anti-tumor effects. ncRNA (non-coding RNA including miRNA and lncRNA long non-coding RNA) plays a key role in cancer development. Quercetin regulates the expression of ncRNAs, which in turn affects the related signalling pathway genes/proteins expression, suppresses the cancer cell growth, promotes cell apoptosis, and enhances sensitivity to chemotherapy agents. Taken together, quercetin is a natural compound with a potential anticancer effect in the adjuvant treatment of cancers.”
