【仅注射一次来自青蛙肠道的细菌，即可消除癌症肿瘤】🐸

日本先端科学技术大学院大学（Japan Advanced Institute of Science and Technology, JAIST）的研究人员从日本树蛙体内分离出一种名为美洲尤文氏菌（Ewingella americana）的细菌。

他们将这种活细菌注射到患有结直肠肿瘤的小鼠血液中。在一项小型实验中，所有五只接受治疗的小鼠在单次注射后肿瘤均完全消退。该研究结果发表在《肠道微生物》（Gut Microbes）杂志上。

它是如何起作用的呢？细菌在肿瘤内部迅速繁殖。它们在低氧环境中生长的能力可能有助于它们在这种环境中生存。实验表明，细菌具有两种互补的作用：🦠 直接破坏癌细胞和 🛡️ 募集免疫细胞攻击肿瘤。

在另一项后续实验中，研究人员在治疗30天后，将同一种癌细胞注射到10只成功接受治疗的小鼠体内。在接下来的30天里，没有一只小鼠出现肿瘤。而所有10只之前未接受治疗的对照小鼠都出现了肿瘤。这表明该细菌对这种特定肿瘤模型具有持久的保护作用。

这仍处于早期动物研究阶段。其对人体的安全性和有效性尚未得到证实，而且这种细菌可能导致人类感染。控制其生长是核心挑战。

我对这项研究的展望是什么？在未来十年，如果我们能够安全地控制这些微生物，那么基因工程改造的微生物可能成为新型药物（尤其是疫苗）的候选者，它们可以摧毁肿瘤并帮助免疫系统识别肿瘤复发。

我关注的下一个里程碑是，在更多癌症模型中进行独立重复验证，并获得更有力的安全证据。

Cancer tumors eliminated by a single injection of bacteria from a frog’s gut. 🐸

Researchers at the Japan Advanced Institute of Science and Technology isolated a bacterium called Ewingella americana from Japanese tree frogs.

They injected the live bacteria into the bloodstream of mice bearing colorectal tumors. In one small experiment, all five treated mice showed complete tumor regression after a single dose. The findings appeared in Gut Microbes.

How did it work? The bacteria multiplied right inside the tumors. Their ability to grow in low-oxygen environments may have helped them thrive inside such environment. Experiments pointed to two complementary effects:🦠 Directly damaging cancer cells and 🛡️ Recruiting immune cells to attack the tumor.

In a separate follow-up experiment, researchers injected the same type of cancer cells into 10 successfully treated mice, 30 days after treatment. None developed tumors during the following 30 days. All 10 previously untreated control mice did. This suggests lasting protection against that particular tumor model.

This remains early animal research. Safety and effectiveness in humans are unproven, and this bacterial species can cause human infections. Controlling its growth is a central challenge.

What's my foresight perspective on that? Over the next decade, engineered microbes could become new candidates for medicines (especially vaccines) that destroy tumors and help the immune system recognize their return, provided we can control these organisms safely.

The next milestone I’d watch is independent replication across more cancer models, alongside stronger safety evidence. http://t.cn/AXY0KngQ